Triple Negative Breast Cancer: A Review

Farheen Sultana, Vijai V Alex


Breast cancer is one of the most common malignancies among women worldwide. Triple negative breast cancer are biologically more aggressive form of breast cancer. Complexity of TNBC at genetic and clinical level elucidates the difficulty in resolving the issue. Absence of estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 makes it cumbersome to treat. Due to activation of MAPK/ERK pathways, TNBC acquires resistance against chemotherapy. TNBC down regulates the expression of regulatory proteins for e.g. BRCA1 and Rb-p53. The present review article is an attempt to briefly discuss the advancement in treatment strategies to overcome complication of TNBC with special reference to several signalling pathways involved in complicating the disease.

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Copyright (c) 2017 Farheen Sultana, Vijai V Alex

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