Mechanistic insight of disease regulation in Breast cancer by miRNA

Nahid Parween, G. Gayathri, Tinku Saroha, Narender Chaudhry

Abstract


Breast cancer has become one of the most frequently diagnosed form of cancer in women. It is heterogeneous in nature with wide range of characteristics features. MicroRNAs (miRNAs) are small non-coding RNA which controls many important biological processes including carcinogenesis. It plays an important role in reatment of breast cancer. In recent years miRNA profiling and deep sequencing has helped in tumor classification and detection and suggested that miRNA expression is dysregulated in cancer. Some of miRNA are associated with breast cancer subtypes by their unique expression pattern, especially with triple negative breast cancer. miRNAs also help in determining breast cancer phenotype and various characters. Another important character of miRNAs is its capacity to regulate the genes of cell cycle progression. Two important cyclins - cyclin D1 and cyclin E interacts with miRNAs, regulating cellular division. This article will provide a brief description about the role of miRNAs in regulating human breast cancer.

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